Abstract
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Animals
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Cell Line, Tumor
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Mice
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Molecular Structure
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Naphthalenes / chemistry
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Protein Binding
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Protein Tyrosine Phosphatases / antagonists & inhibitors*
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Protein Tyrosine Phosphatases / classification
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Protein Tyrosine Phosphatases / metabolism*
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Rhodanine / chemical synthesis
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Rhodanine / chemistry*
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Rhodanine / pharmacology*
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Structure-Activity Relationship
Substances
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Aldehydes
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Enzyme Inhibitors
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Naphthalenes
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salicylaldehyde
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naphthalene
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Rhodanine
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Protein Tyrosine Phosphatases